Late-life depression (LLD) is a highly prevalent mood disorder occurring in older adults and is frequently accompanied by cognitive impairment (CI). Studies have shown that LLD may increase the risk of Alzheimer's disease (AD). However, the heterogeneity of presentation of geriatric depression suggests that multiple biological mechanisms may underlie it. Current biological research on LLD progression incorporates machine learning that combines neuroimaging data with clinical observations. There are few studies on incident cognitive diagnostic outcomes in LLD based on structural MRI (sMRI). In this paper, we describe the development of a hybrid representation learning (HRL) framework for predicting cognitive diagnosis over 5 years based on T1-weighted sMRI data. Specifically, we first extract prediction-oriented MRI features via a deep neural network, and then integrate them with handcrafted MRI features via a Transformer encoder for cognitive diagnosis prediction. Two tasks are investigated in this work, including (1) identifying cognitively normal subjects with LLD and never-depressed older healthy subjects, and (2) identifying LLD subjects who developed CI (or even AD) and those who stayed cognitively normal over five years. To the best of our knowledge, this is among the first attempts to study the complex heterogeneous progression of LLD based on task-oriented and handcrafted MRI features. We validate the proposed HRL on 294 subjects with T1-weighted MRIs from two clinically harmonized studies. Experimental results suggest that the HRL outperforms several classical machine learning and state-of-the-art deep learning methods in LLD identification and prediction tasks.

Autonomous robotic surgery has advanced significantly based on analysis of visual and temporal cues in surgical workflow, but relational cues from domain knowledge remain under investigation. Complex relations in surgical annotations can be divided into intra- and inter-relations, both valuable to autonomous systems to comprehend surgical workflows. Intra- and inter-relations describe the relevance of various categories within a particular annotation type and the relevance of different annotation types, respectively. This paper aims to systematically investigate the importance of relational cues in surgery. First, we contribute the RLLS12M dataset, a large-scale collection of robotic left lateral sectionectomy (RLLS), by curating 50 videos of 50 patients operated by 5 surgeons and annotating a hierarchical workflow, which consists of 3 inter- and 6 intra-relations, 6 steps, 15 tasks, and 38 activities represented as the triplet of 11 instruments, 8 actions, and 16 objects, totaling 2,113,510 video frames and 12,681,060 annotation entities. Correspondingly, we propose a multi-relation purification hybrid network (MURPHY), which aptly incorporates novel relation modules to augment the feature representation by purifying relational features using the intra- and inter-relations embodied in annotations. The intra-relation module leverages a R-GCN to implant visual features in different graph relations, which are aggregated using a targeted relation purification with affinity information measuring label consistency and feature similarity. The inter-relation module is motivated by attention mechanisms to regularize the influence of relational features based on the hierarchy of annotation types from the domain knowledge. Extensive experimental results on the curated RLLS dataset confirm the effectiveness of our approach, demonstrating that relations matter in surgical workflow analysis.

Many real-world applications of language models (LMs), such as code autocomplete and writing assistance, involve human-LM interaction, but the main LM benchmarks are non-interactive, where a system produces output without human intervention. To evaluate human-LM interaction, we develop a framework, Human-AI Language-based Interaction Evaluation (H-LINE), that expands non-interactive evaluation along three dimensions, capturing (i) the interactive process, not only the final output; (ii) the first-person subjective experience, not just a third-party assessment; and (iii) notions of preference beyond quality. We then design five tasks ranging from goal-oriented to open-ended to capture different forms of interaction. On four state-of-the-art LMs (three variants of OpenAI's GPT-3 and AI21's J1-Jumbo), we find that non-interactive performance does not always result in better human-LM interaction and that first-person and third-party metrics can diverge, suggesting the importance of examining the nuances of human-LM interaction.

The number of international benchmarking competitions is steadily increasing in various fields of machine learning (ML) research and practice. So far, however, little is known about the common practice as well as bottlenecks faced by the community in tackling the research questions posed. To shed light on the status quo of algorithm development in the specific field of biomedical imaging analysis, we designed an international survey that was issued to all participants of challenges conducted in conjunction with the IEEE ISBI 2021 and MICCAI 2021 conferences (80 competitions in total). The survey covered participants' expertise and working environments, their chosen strategies, as well as algorithm characteristics. A median of 72% challenge participants took part in the survey. According to our results, knowledge exchange was the primary incentive (70%) for participation, while the reception of prize money played only a minor role (16%). While a median of 80 working hours was spent on method development, a large portion of participants stated that they did not have enough time for method development (32%). 25% perceived the infrastructure to be a bottleneck. Overall, 94% of all solutions were deep learning-based. Of these, 84% were based on standard architectures. 43% of the respondents reported that the data samples (e.g., images) were too large to be processed at once. This was most commonly addressed by patch-based training (69%), downsampling (37%), and solving 3D analysis tasks as a series of 2D tasks. K-fold cross-validation on the training set was performed by only 37% of the participants and only 50% of the participants performed ensembling based on multiple identical models (61%) or heterogeneous models (39%). 48% of the respondents applied postprocessing steps.

This paper presents an algorithm to solve the Soft k-Means problem globally. Unlike Fuzzy c-Means, Soft k-Means (SkM) has a matrix factorization-type objective and has been shown to have a close relation with the popular probability decomposition-type clustering methods, e.g., Left Stochastic Clustering (LSC). Though some work has been done for solving the Soft k-Means problem, they usually use an alternating minimization scheme or the projected gradient descent method, which cannot guarantee global optimality since the non-convexity of SkM. In this paper, we present a sufficient condition for a feasible solution of Soft k-Means problem to be globally optimal and show the output of the proposed algorithm satisfies it. Moreover, for the Soft k-Means problem, we provide interesting discussions on stability, solutions non-uniqueness, and connection with LSC. Then, a new model, named Minimal Volume Soft k-Means (MVSkM), is proposed to address the solutions non-uniqueness issue. Finally, experimental results support our theoretical results.

It is a common sense that datasets with high-quality data samples play an important role in artificial intelligence (AI), machine learning (ML) and related studies. However, although AI/ML has been introduced in wireless researches long time ago, few datasets are commonly used in the research community. Without a common dataset, AI-based methods proposed for wireless systems are hard to compare with both the traditional baselines and even each other. The existing wireless AI researches usually rely on datasets generated based on statistical models or ray-tracing simulations with limited environments. The statistical data hinder the trained AI models from further fine-tuning for a specific scenario, and ray-tracing data with limited environments lower down the generalization capability of the trained AI models. In this paper, we present the Wireless AI Research Dataset (WAIR-D)1, which consists of two scenarios. Scenario 1 contains 10,000 environments with sparsely dropped user equipments (UEs), and Scenario 2 contains 100 environments with densely dropped UEs. The environments are randomly picked up from more than 40 cities in the real world map. The large volume of the data guarantees that the trained AI models enjoy good generalization capability, while fine-tuning can be easily carried out on a specific chosen environment. Moreover, both the wireless channels and the corresponding environmental information are provided in WAIR-D, so that extra-information-aided communication mechanism can be designed and evaluated. WAIR-D provides the researchers benchmarks to compare their different designs or reproduce results of others. In this paper, we show the detailed construction of this dataset and examples of using it.

Recent works on Lottery Ticket Hypothesis have shown that pre-trained language models (PLMs) contain smaller matching subnetworks(winning tickets) which are capable of reaching accuracy comparable to the original models. However, these tickets are proved to be notrobust to adversarial examples, and even worse than their PLM counterparts. To address this problem, we propose a novel method based on learning binary weight masks to identify robust tickets hidden in the original PLMs. Since the loss is not differentiable for the binary mask, we assign the hard concrete distribution to the masks and encourage their sparsity using a smoothing approximation of L0 regularization.Furthermore, we design an adversarial loss objective to guide the search for robust tickets and ensure that the tickets perform well bothin accuracy and robustness. Experimental results show the significant improvement of the proposed method over previous work on adversarial robustness evaluation.

Graph structure learning aims to learn connectivity in a graph from data. It is particularly important for many computer vision related tasks since no explicit graph structure is available for images for most cases. A natural way to construct a graph among images is to treat each image as a node and assign pairwise image similarities as weights to corresponding edges. It is well known that pairwise similarities between images are sensitive to the noise in feature representations, leading to unreliable graph structures. We address this problem from the viewpoint of statistical tests. By viewing the feature vector of each node as an independent sample, the decision of whether creating an edge between two nodes based on their similarity in feature representation can be thought as a ${\it single}$ statistical test. To improve the robustness in the decision of creating an edge, multiple samples are drawn and integrated by ${\it multiple}$ statistical tests to generate a more reliable similarity measure, consequentially more reliable graph structure. The corresponding elegant matrix form named $\mathcal{B}\textbf{-Attention}$ is designed for efficiency. The effectiveness of multiple tests for graph structure learning is verified both theoretically and empirically on multiple clustering and ReID benchmark datasets. Source codes are available at https://github.com/Thomas-wyh/B-Attention.

有效的缩放和灵活的任务接口使大型语言模型能够在许多任务中表现出色。帕利（Pali）根据视觉和文本输入生成文本，并使用该界面以许多语言执行许多视觉，语言和多模式任务。为了训练帕利，我们利用了大型的编码器语言模型和视觉变压器（VITS）。这使我们能够利用其现有能力，并利用培训它们的大量成本。我们发现，视觉和语言组成部分的联合缩放很重要。由于现有的语言变压器比其视觉对应物要大得多，因此我们训练迄今为止最大的VIT（VIT-E），以量化甚至大容量视觉模型的好处。为了训练Pali，我们基于一个新的图像文本训练集，其中包含10B图像和文本，以100多种语言来创建大型的多语言组合。帕利（Pali）在多个视觉和语言任务（例如字幕，视觉问题，索方式，场景文本理解）中实现了最新的，同时保留了简单，模块化和可扩展的设计。

随着计算能力的兴起，使用数据驱动的方法来共同设计机器人的形态和控制器已成为一种可行的方法。然而，评估每个形态下控制器的适应性是耗时的。作为开创性数据驱动的方法，共同适应利用了双NETWORK机制，目的是学习以形态学参数为条件的Q功能，以取代对各种候选者的传统评估，从而加快优化的速度。在本文中，我们发现共同适应在参数传输期间训练和状态行动分布变化期间的勘探误差的存在，这损害了性能。我们提出了在线和离线RL方法的并发网络的框架。通过灵活地利用行为克隆术语，我们可以减轻上述问题对结果的影响。进行仿真和物理实验以证明我们所提出的方法优于基线算法，这说明了所提出的方法是发现形态和控制器的最佳组合的有效方法。